Water → N1-[4-(5-isoquinolylsulfonyl)phenyl]acetamide

HRID 619718ノート

反応式

HRID 619718 の反応式
[CH:1]1[C:10]2[C:5](=[C:6]([S:11]([C:14]3[CH:20]=[CH:19][C:17]([NH2:18])=[CH:16][CH:15]=3)(=[O:13])=[O:12])[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1.O.[C:22](OC(=O)C)(=[O:24])[CH3:23]>N1C=CC=CC=1>[CH:1]1[C:10]2[C:5](=[C:6]([S:11]([C:14]3[CH:20]=[CH:19][C:17]([NH:18][C:22](=[O:24])[CH3:23])=[CH:16][CH:15]=3)(=[O:13])=[O:12])[CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][N:2]=1

参加物

5

反応物 3

HCID 962WaterHCID 7918Acetic AnhydrideHCID 21846995HCID 21846995、化合物

生成物 1

HCID 15435686N1-[4-(5-isoquinolylsulfonyl)phenyl]acetamide収率 44.3%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

4-(5-Isoquinolylsulfonyl)aniline 20 mg (0.1 mmol) was dissolved in a mixture solution of acetic anhydride 2 ml and pyridine 2 ml, the mixture was stirred overnight at room temperature, water was added to the reaction solution, and the solution was extracted with ethyl acetate. The organic layer was washed with saturated potassium hydrogensulfate and with saturated sodium hydrogencarbonate, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give N1-[4-(5-isoquinolylsulfonyl)phenyl]acetamide 10 mg (44.3%)

後処理

  1. extractionthe solution was extracted with ethyl acetate
  2. washThe organic layer was washed with saturated potassium hydrogensulfate and with saturated sodium hydrogencarbonate
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-ca7d9bb79b48448b8509309580b6ebee
出典データセット
uspto-grants-1999_09
特許番号
US05959107

反応ノート

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