Ethanesulfonylchloride, 2-chloro- → HCID 54097682、化合物

反応式

Cl.[NH2:2][C@H:3]1[CH2:7][CH2:6][N:5]([CH2:8][C:9]2[CH:10]=[C:11]([CH:14]=[CH:15][CH:16]=2)[C:12]#[N:13])[C:4]1=[O:17].Cl[CH2:19][CH2:20][S:21](Cl)(=[O:23])=[O:22]>>[C:12]([C:11]1[CH:10]=[C:9]([CH:16]=[CH:15][CH:14]=1)[CH2:8][N:5]1[CH2:6][CH2:7][C@H:3]([NH:2][S:21]([CH:20]=[CH2:19])(=[O:23])=[O:22])[C:4]1=[O:17])#[N:13]

参加物

反応物 2

HCID 15385Ethanesulfonylchloride, 2-chloro-

HCID 228707863-(3-(S)-Amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride

生成物 1

HCID 54097682HCID 54097682、化合物

実験手順

The title compound is prepared from 3-(3-(S)-amino-2-oxopyrrolidin-1-ylmethyl)benzonitrile hydrochloride as in EXAMPLE 24, Part B using 2-chloroethanesulfonyl chloride in place of 6-methoxynaphthalene-2-sulfonyl chloride. The crude product is purified by column chromatography in a gradient of 10% EtOAc/CH2Cl2 to 40% EtOAc/CH2Cl2 to afford the title compound as a solid.

後処理

customThe crude product is purified by column chromatography in a gradient of 10% EtOAc/CH2Cl2 to 40% EtOAc/CH2Cl2

出典と根拠

ORDレコード: ord-ce4d60ff71104811a812d48c494b6a19
出典データセット: uspto-grants-1999_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05958918

反応ノート

読み込み中…

参加物