HCID 68704968、化合物 → HCID 136388716、化合物
反応式
C[O:2][C:3]1[CH:4]=[C:5]([C:14]2[CH:19]=[CH:18][N:17]=[C:16]([C:20]3[C:21]([C:26]([F:29])([F:28])[F:27])=[N:22][CH:23]=[CH:24][CH:25]=3)[N:15]=2)[CH:6]=[C:7]([N+:11]([O-:13])=[O:12])[C:8]=1[O:9]C>Br>[N+:11]([C:7]1[CH:6]=[C:5]([C:14]2[CH:19]=[CH:18][N:17]=[C:16]([C:20]3[C:21]([C:26]([F:29])([F:28])[F:27])=[N:22][CH:23]=[CH:24][CH:25]=3)[N:15]=2)[CH:4]=[C:3]([OH:2])[C:8]=1[OH:9])([O-:13])=[O:12]参加物
3
反応条件
- 温度
- 140 °C
実験手順
A suspension of 4-(3,4-dimethoxy-5-nitrophenyl)-2-(2-(trifluoromethyl)pyridin-3-yl)pyrimidine (0.239 g, 0.59 mmol) in 48% hydrobromic acid (5 mL) was stirred at 140° C. for four hours and then allowed to cool to room temperature. The mixture was poured onto ice-water (100 mL) and the resulting filtrate was filtered off, washed with water and dried to give 3-nitro-5-(2-(2-(trifluoromethyl)pyridin-3-yl)pyrimidin-4-yl)benzene-1,2-diol, 0.201 g (90%).
後処理
- temperature