Acetone → 3-chloro-N-phenylpropanamide

HRID 620008ノート

反応式

HRID 620008 の反応式
[Cl:1][CH2:2][CH2:3][C:4](Cl)=[O:5].CC(C)=O.[NH2:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.Cl>O>[Cl:1][CH2:2][CH2:3][C:4]([NH:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)=[O:5]

参加物

6

反応物 4

HCID 180Acetone2 回HCID 313Hydrochloric AcidHCID 6115AnilineHCID 693643-Chloropropionyl chloride

生成物 1

HCID 2404043-chloro-N-phenylpropanamide

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 3-chloropropionyl chloride (300 ml) and acetone (600 ml) is added dropwise to a refluxing mixture of aniline (575 ml) and acetone (600 ml). The reaction mixture is refluxed for one hour, cooled in an ice bath, and poured into a mixture of 6N HCl (500 ml) and water (3.5 l). The resulting solid is filtered, washed with water, and dried, yielding the desired product, M.P. 114°-115.5° C.

後処理

  1. temperatureThe reaction mixture is refluxed for one hour
  2. temperaturecooled in an ice bath
  3. filtrationThe resulting solid is filtered
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-6d3202c895954af697ce840462fbfe2a
出典データセット
uspto-grants-1989_04
特許番号
US04818755

反応ノート

読み込み中…