Chloroacetic Acid → 2-(chloromethyl)-1-(3-fluorophenyl)-1H-1,3-benzodiazole

HRID 620034ノート

反応式

HRID 620034 の反応式
[F:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[NH2:15])[CH:5]=[CH:6][CH:7]=1.[Cl:16][CH2:17][C:18](O)=O.C(=O)([O-])[O-].[Na+].[Na+]>O>[F:1][C:2]1[CH:3]=[C:4]([N:8]2[C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:15]=[C:18]2[CH2:17][Cl:16])[CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 300Chloroacetic AcidHCID 10340Sodium CarbonateHCID 21248421HCID 21248421、化合物

生成物 1

HCID 212484162-(chloromethyl)-1-(3-fluorophenyl)-1H-1,3-benzodiazole

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
130 °C

実験手順

A mixture of N-(3-fluorophenyl)-o-phenylenediamine (0.8 g, 4 mmol) prepared in the preceding step (a), polyphosphoric ester (2.7 g) and monochloroacetic acid (0.4 g, 4.2 mmol) was heated for 1 hour at 130° C. and water was added to the reaction mixture to decompose an excess of polyphosphoric ester, then neutralized with sodium carbonate and the occurred oily substance was extracted with chloroform and the extract was washed, dried and concentrated in vacuo.

後処理

  1. extractionthe occurred oily substance was extracted with chloroform
  2. washthe extract was washed
  3. customdried
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-c8562ea73a6143e88762b9fffa07ae2d
出典データセット
uspto-grants-1989_04
特許番号
US04818761

反応ノート

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