Hydrochloric Acid → 5-[3,4-Bis(benzyloxy)-5-nitrophenyl]-2H-tetrazole

HRID 62008ノート

反応式

HRID 62008 の反応式
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:14]=[C:15]([N+:25]([O-:27])=[O:26])[C:16]=1[O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:12]#[N:13])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N-:28]=[N+:29]=[N-:30].[Na+].[Cl-].[NH4+].Cl>CN(C)C=O>[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([C:12]2[N:28]=[N:29][NH:30][N:13]=2)[CH:14]=[C:15]([N+:25]([O-:27])=[O:26])[C:16]=1[O:17][CH2:18][C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 670369943,4-Bis(benzyloxy)-5-nitrobenzonitrile

生成物 1

HCID 670370545-[3,4-Bis(benzyloxy)-5-nitrophenyl]-2H-tetrazole

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
85 °C

実験手順

A mixture of 3,4-bis-benzyloxy-5-nitro-benzonitrile (0.54 g, 1.50 mmol), sodium azide (0.15 g, 2.25 mmol) and ammonium chloride (0.12 g, 2.25 mmol) in dimethylformamide (3 mL) was stirred at 85° C. for 20 hours. After cooling to room temperature, the reaction mixture was poured onto water (30 mL) and acidified with dilute hydrochloric acid. The resulting precipitate was collected, washed with water and dried to yield 5-(3,4-bis-benzyloxy-5-nitrophenyl)-2H-tetrazole, 0.53 g (87%).

後処理

  1. temperatureAfter cooling to room temperature
  2. additionthe reaction mixture was poured onto water (30 mL)
  3. customThe resulting precipitate was collected
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-e6af85c9b6ec47b3b044a76fc1298ea1
出典データセット
uspto-grants-2016_09
特許番号
US09446012B2

反応ノート

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