[NH2-].[Na+].CCOCC.[Cl:8][C:9]1[CH:10]=[C:11]([CH2:16][C:17]#[N:18])[CH:12]=[CH:13][C:14]=1[Cl:15].[CH2:19]([CH:26]1[CH2:31][CH2:30][N:29]([CH2:32][CH2:33]Cl)[CH2:28][CH2:27]1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1>O>[CH2:19]([CH:26]1[CH2:31][CH2:30][N:29]([CH2:32][CH2:33][CH:16]([C:11]2[CH:12]=[CH:13][C:14]([Cl:15])=[C:9]([Cl:8])[CH:10]=2)[C:17]#[N:18])[CH2:28][CH2:27]1)[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=11.95 g of sodium amide are added in small quantities to an ether solution of 9.3 g of 3,4-dichlorophenylacetonitrile. The mixture is heated for 2 hours to reflux, 11.8 g of 2-(4-benzylpiperidino)-1-chloro ethane are added and heating is repeated for another 5 hours to reflux. The resulting mixture is cooled and 200 ml of water are added, after what the organic phase is decanted, washed with water and extracted with a 10% solution of hydrochloric acid. The aqueous phase is then neutralized with soda, extracted with ether, washed with water, dried over magnesium sulfate and evaporated. 13 g of oily product are thus obtained.
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