Hydrazine hydrate (1:1) → 6-(2-amino-indan-5-yl)-4,5-dihydropyridazin-3(2H)-one
反応式
O.[NH2:2][NH2:3].Cl.[NH2:5][CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:15](=O)[CH2:16][CH2:17][C:18]([O:20]C)=O)[CH:12]=2)[CH2:7]1>C(O)(=O)C>[NH2:5][CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[C:11]([C:15]3[CH2:16][CH2:17][C:18](=[O:20])[NH:2][N:3]=3)[CH:12]=2)[CH2:7]1参加物
4
実験手順
8.5 g (0.17 mol) of 99% hydrazine hydrate are added to 10.0 g (0.035 mol) of methyl 4-(2-amino-indan-5-yl)-4-oxobutyrate hydrochloride in glacial acetic acid and the mixture is boiled for 30 minutes. The mixture is evaporated in vacuo, the residue is dissolved in water and the reaction product is precipitated by neutralisation with sodium hydroxide.
後処理
- customThe mixture is evaporated in vacuo
- dissolutionthe residue is dissolved in water
- customthe reaction product is precipitated by neutralisation with sodium hydroxide
出典と根拠
- ORDレコード
- ord-9c5bb891a85840e4aad887e05035831e
- 出典データセット
- uspto-grants-1989_04
- 特許番号
- US04820705
反応ノート
読み込み中…