Hydrazine hydrate (1:1) → 6-(2-Benzenesulphonamido-indan-5-yl)-4,5-dihydropyridazin-3(2H)-one

HRID 620205ノート

反応式

HRID 620205 の反応式
[C:1]1([S:7]([NH:10][CH:11]2[CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:20](=O)[CH2:21][CH2:22][C:23]([OH:25])=O)[CH:17]=3)[CH2:12]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O.[NH2:28][NH2:29]>C(O)(=O)C>[C:1]1([S:7]([NH:10][CH:11]2[CH2:19][C:18]3[C:13](=[CH:14][CH:15]=[C:16]([C:20]4[CH2:21][CH2:22][C:23](=[O:25])[NH:28][N:29]=4)[CH:17]=3)[CH2:12]2)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 14071508HCID 14071508、化合物

生成物 1

HCID 140715226-(2-Benzenesulphonamido-indan-5-yl)-4,5-dihydropyridazin-3(2H)-one

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

3.0 g (8 mmol) of 4-(2-benzenesulphonamido-indan-5-yl)-4-oxobutyric acid and 0.53 g (10.4 mmol) of 99% hydrazine hydrate in 12 ml of glacial acetic acid are boiled for 3 hours. The mixture is evaporated in vacuo, water is added to the residue, which is neutralised with sodium carbonate solution, and the reaction product is filtered off with suction and recrystallised from n-propanol.

後処理

  1. customThe mixture is evaporated in vacuo, water
  2. additionis added to the residue, which
  3. filtrationthe reaction product is filtered off with suction
  4. customrecrystallised from n-propanol

出典と根拠

ORDレコード
ord-2a89c6f2fa634af5816ac95578bbb7ad
出典データセット
uspto-grants-1989_04
特許番号
US04820705

反応ノート

読み込み中…