Nitric Acid → HCID 178526762、化合物

HRID 62025

反応式

HRID 62025 の反応式
[N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([OH:11])=[CH:3][CH:2]=1.[N+:12]([O-])([OH:14])=[O:13]>C(O)(=O)CC.C(O)C>[N+:12]([C:3]1[CH:2]=[N:1][C:10]2[C:5]([C:4]=1[OH:11])=[CH:6][CH:7]=[CH:8][CH:9]=2)([O-:14])=[O:13]

参加物

5

反応物 2

HCID 944Nitric AcidHCID 178516385quinolin-4-ol

生成物 1

HCID 178526762HCID 178526762、化合物

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒2 回HCID 1032Propionic Acid溶媒

反応条件

温度
125 °C

実験手順

A mixture of quinolin-4-ol (1 eq.) in propionic acid was heated to 125° C. with stirring. Nitric acid (2.2 eq.) was added drop wise to the stirred solution while maintaining the reaction mixture temperature at 125° C. Reaction was stirred at 125° C. for 15 min. and cooled to ambient temperature. The reaction was diluted with ethanol and solid was collected by vacuum filtration. Solid was washed successively with ethanol, water and ethanol. Resulting yellow solid was heated in refluxing ethanol and filtered from hot mixture to give pure 3-nitro-quinoline-4-ol.

後処理

  1. temperaturewhile maintaining the reaction mixture temperature at 125° C
  2. customReaction
  3. stirringwas stirred at 125° C. for 15 min.
  4. temperaturecooled to ambient temperature
  5. filtrationwas collected by vacuum filtration
  6. washSolid was washed successively with ethanol, water and ethanol
  7. customResulting yellow solid
  8. temperaturewas heated
  9. filtrationfiltered from hot mixture

出典と根拠

ORDレコード
ord-e3929725edc44b4791055f004d72daca
出典データセット
uspto-grants-2016_09
特許番号
US09446040B2

関連ノート

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