Hydrochloric Acid → 3,4-Dimethoxycinnamohydroxamic acid

HRID 620406

反応式

HRID 620406 の反応式
Cl.[NH2:2][OH:3].[OH-].[K+].[CH3:6][O:7][C:8]1[CH:9]=[C:10]([CH:17]=[CH:18][C:19]=1[O:20][CH3:21])[CH:11]=[CH:12][C:13](OC)=[O:14].Cl>CO>[CH3:6][O:7][C:8]1[CH:9]=[C:10]([CH:17]=[CH:18][C:19]=1[O:20][CH3:21])[CH:11]=[CH:12][C:13]([NH:2][OH:3])=[O:14]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 94307Methyl 3,4-dimethoxycinnamateHCID 443297Hydroxyamine hydrochloride

生成物 1

HCID 329133,4-Dimethoxycinnamohydroxamic acid収率 84%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

反応条件

温度
0 °C

実験手順

A solution of hydroxylamine hydrochloride (5.09 g, 72 mmol) in methanol (26 ml) was added to a solution of 88% potassium hydroxide (6.99 g, 109 mmol) in methanol (15.3 ml), keeping the temperature below 40° C. The mixture was cooled to 0° C., filtered, and methyl 3,4-dimethoxycinnamate (8.0 g, 36 mmol) was added to the filtrate. After two hours, concentrated HCl (5 ml) was added to the cold solution. The resulting precipitate was filtered, washed with water and ether, and dried in vacuo, to give 6.74 g (84% yield) of the named compound, mp 183°-185° C.

後処理

  1. customthe temperature below 40° C
  2. filtrationfiltered
  3. filtrationThe resulting precipitate was filtered
  4. washwashed with water and ether
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-0ccc845c683e4ffc8d6174324d73e56a
出典データセット
uspto-grants-1989_04
特許番号
US04820828

関連ノート

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