1-Pyrenecarboxaldehyde → 3-Methoxy-2-methyl-2-((7-pyrenylmethyl)amino)-1-propanol methanesulfonate

HRID 620526

反応式

HRID 620526 の反応式
Cl.[C:2]1(CN[C@@](C)([C@@H](O)C)CO)[C:15]2[C:16]3=[C:17]4[C:12](=[CH:13][CH:14]=2)[CH:11]=[CH:10][CH:9]=[C:8]4[CH:7]=[CH:6][C:5]3=[CH:4][CH:3]=1.C1(C=O)C2C3=C4C(=CC=2)C=CC=C4C=CC3=CC=1.NC(C)(COC)CO.[CH3:53][S:54]([O:57][CH2:58][C:59]([CH3:81])([NH:63][CH2:64]C1C2C3=C4C(=CC=2)C=CC=C4C=CC3=CC=1)[CH2:60][O:61][CH3:62])(=[O:56])=[O:55]>>[CH3:53][S:54]([O:57][CH2:58][C:59]([CH3:81])([NH:63][CH2:64][C:3]1[CH:4]=[C:5]2[C:16]3=[C:17]4[C:8](=[CH:9][CH:10]=[CH:11][C:12]4=[CH:13][CH:14]=[C:15]3[CH:2]=1)[CH:7]=[CH:6]2)[CH2:60][O:61][CH3:62])(=[O:56])=[O:55]

参加物

5

反応物 4

HCID 2328481-PyrenecarboxaldehydeHCID 133754152-Amino-3-methoxy-2-methylpropan-1-olHCID 86742932(+-)(2R*,3S*)-2-((1-Pyrenylmethyl)amino)-2-methyl-1,3-butanediol hydrochlorideHCID 886453263-Methoxy-2-methyl-2-((1-pyrenylmethyl)amino)-1-propanol methanesulfonate

生成物 1

HCID 536384113-Methoxy-2-methyl-2-((7-pyrenylmethyl)amino)-1-propanol methanesulfonate

実験手順

Using the reductive amination procedure outlined in 20G, pyrene-1-carbaldehyde (Aldrich) and 2-amino-3-methoxy-2-methyl-1-propanol (22C) gave after workup using the procedure outlined in 1B 3-methoxy-2-methyl-2-((1-pyrenylmethyl)amino)-1-propanol methanesulfonate.1/3H2O mp 158°-160°, (EtOH/Et2O), (C, H, N, S).

後処理

  1. customgave after workup

出典と根拠

ORDレコード
ord-a8dd000b0bbd490a90074a43bb0df29b
出典データセット
uspto-grants-1989_04
特許番号
US04820873

関連ノート

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