Potassium Carbonate → N-Hydroxyhexyl-1,2,3,4-tetrahydroquinoline

HRID 6206

反応式

HRID 6206 の反応式
[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.Br[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][OH:18].C(=O)([O-])[O-].[K+].[K+]>C1(C)C=CC=CC=1>[OH:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 694601,2,3,4-TetrahydroquinolineHCID 779706-Bromo-1-hexanol

生成物 1

HCID 19795093N-Hydroxyhexyl-1,2,3,4-tetrahydroquinoline

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A stirred solution of 133.2 g (1 mole) of 1,2,3,4-tetrahydroquinoline, 181.1 g (1 mole) of 6-bromohexanol, and 138.2 g (1 mole) of potassium carbonate in toluene is heated at 80° C. for 3 hours. The solution is cooled to room temperature, and the solids are removed by filtration. The solvent is removed in vacuo, and the N-hydroxyhexyltetrahydroquinoline is purified by chromatography (silica gel, hexane:ethyl acetate).

後処理

  1. customthe solids are removed by filtration
  2. customThe solvent is removed in vacuo
  3. customthe N-hydroxyhexyltetrahydroquinoline is purified by chromatography (silica gel, hexane:ethyl acetate)

出典と根拠

ORDレコード
ord-002d9f5f7d094a87a267a18d90638473
出典データセット
uspto-grants-1993_09
特許番号
US05247042

関連ノート

読み込み中…