反応式
[CH2:1]([C:4]1[CH:5]=[N:6][N:7]([CH3:13])[C:8]=1[S:9]([NH2:12])(=[O:11])=[O:10])[CH:2]=[CH2:3].C1(N[C:21](=O)[O-:22])C=CC=CC=1.[CH3:24][O:25][C:26]1[CH:31]=[C:30]([O:32][CH3:33])[N:29]=[C:28]([NH2:34])[N:27]=1.N12CCCN=C1CCCCC2.Cl>C(#N)C>[CH3:24][O:25][C:26]1[CH:31]=[C:30]([O:32][CH3:33])[N:29]=[C:28]([NH:34][C:21]([NH:12][S:9]([C:8]2[N:7]([CH3:13])[N:6]=[CH:5][C:4]=2[CH:1]=[CH:2][CH3:3])(=[O:11])=[O:10])=[O:22])[N:27]=1参加物
7
反応物 5
生成物 1
試薬・触媒・溶媒 1
実験手順
The sulfonamide from Example 4 (150 mg, 0.7 mmol) and the phenylcarbamate of 4,6-dimethoxy-2-aminopyrimidine (202 mg, 0.7 mmol) were dissolved in 5 ml of acetonitrile. 1,8-Diazabicyclo[5.4.0]undec-7-ene (112 mg, 0.7 mmol) was added and the reaction was stirred for 30 minutes. Addition of 5 ml of 5% hydrochloric acid resulted in a solid, which was collected and dried to afford 280 mg of the desired product, m.p. 154°-156° C.
後処理
- customresulted in a solid, which
- customwas collected
- customdried
出典と根拠
- ORDレコード
- ord-6e38367568eb4d5d867d853c97ed715c
- 出典データセット
- uspto-grants-1989_04
- 特許番号
- US04822403
関連ノート
読み込み中…