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Triethylamine → 2-Hydroxy-2-phenylethyl 4'-(6-hydroxyhexyloxy)-(1,1')-biphenyl-4-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | Epoxy-styrene | HCID 14299145 | — |
| 反応物 | 4-(6-Hydroxyhexyloxy)biphenyl-4'-carboxylic acid | HCID 22242497 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 2-Hydroxy-2-phenylethyl 4'-(6-hydroxyhexyloxy)-(1,1')-biphenyl-4-carboxylate | HCID 21243981 | — |
反応手順
A solution of 26.6 g of 4'-(6-hydroxyhexyloxy)(1,1')-biphenyl-4-carboxylic acid, 16 g of epoxystyrene and 16 g of triethylamine in 300 ml of tetrahydrofuran is heated at the boiling point for 140 hours. It is diluted with 1000 ml of methylene chloride, washed twice with 2N hydrochloric acid and dried over sodium sulfate. After concentration under reduced pressure, the residue is crystallized from ethanol. 2-Hydroxy-2-phenylethyl 4'-(6-hydroxyhexyloxy)-(1,1')-biphenyl-4-carboxylate is obtained; melting point: 148°-150°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04822682 |
| 出典データセット | uspto-grants-1989_04 |
| ORD ID | ord-eed9bfa7fce04b72ba6f37a25675ea79 |
| 出典メモ | uspto-grants-1989_04 |