Hydrochloric Acid → 2-(p-Nitrophenoxy)-myristic acid

HRID 620702ノート

反応式

HRID 620702 の反応式
C([O:3][C:4](=[O:28])[CH:5]([O:18][C:19]1[CH:24]=[CH:23][C:22]([N+:25]([O-:27])=[O:26])=[CH:21][CH:20]=1)[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])C.C(OC(=O)C(OC1C=CC=C([N+]([O-])=O)C=1)CCCCCCCCCCCC)C.[OH-].[Na+].Cl>C(O)C>[N+:25]([C:22]1[CH:21]=[CH:20][C:19]([O:18][CH:5]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17])[C:4]([OH:28])=[O:3])=[CH:24][CH:23]=1)([O-:27])=[O:26]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 14122414Ethyl 2-(3-nitrophenoxy)tetradecanoateHCID 54095639Ethyl 2-(4-nitrophenoxy)tetradecanoate

生成物 1

HCID 37465002-(p-Nitrophenoxy)-myristic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 980 g of 2-(p-nitrophenoxy)-myristic acid ethyl ester (synthesized analogously to the 2-(m-nitrophenoxy)-myristic acid ethyl ester of Preparation 1), 375 ml of 10N sodium hydroxide, and 1500 ml of ethanol is stirred for 1 h at room temperature and next acidified with 5000 ml of 1N hydrochloric acid. The resulting precipitate is filtered off, rinsed with water until neutral, and dried. The product (845 g) was recrystallized from n-hexane.

後処理

  1. filtrationThe resulting precipitate is filtered off
  2. washrinsed with water until neutral, and
  3. customdried
  4. customThe product (845 g) was recrystallized from n-hexane

出典と根拠

ORDレコード
ord-a866a4cb93004cd1b249373b89c0efd7
出典データセット
uspto-grants-1989_04
特許番号
US04822729

反応ノート

読み込み中…