4-Fluoroiodobenzene → 2-[3-(4-fluorophenyl)-2E-propenyl]-1H-isoindole-1,3(2H)-dione

HRID 620740

反応式

HRID 620740 の反応式
[CH2:1]([N:4]1[C:8](=[O:9])[C:7]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:6]2[C:5]1=[O:14])[CH:2]=[CH2:3].[F:15][C:16]1[CH:21]=[CH:20][C:19](I)=[CH:18][CH:17]=1>C(#N)C.CC([O-])=O.CC([O-])=O.[Pd+2]>[F:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:3]/[CH:2]=[CH:1]/[N:4]2[C:8](=[O:9])[C:7]3[C:6](=[CH:13][CH:12]=[CH:11][CH:10]=3)[C:5]2=[O:14])=[CH:18][CH:17]=1

参加物

5

反応物 2

HCID 96054-FluoroiodobenzeneHCID 224401N-Allylphthalimide

生成物 1

HCID 703628262-[3-(4-fluorophenyl)-2E-propenyl]-1H-isoindole-1,3(2H)-dione

試薬・触媒・溶媒 2

HCID 167845palladium(II) acetate触媒HCID 6342Acetonitrile溶媒

実験手順

N-Allylphthalimide (13.9 g, 74.3 mmol), 1-fluoro-4-iodobenzene (15.0 g, 67.6 mmol) triethylamine (15.0 g, 148 mmol) and Pd(OAc)2 (152 mg) were heated at 104° in a glass bomb with shaking for 18 h under an inert atmosphere. The reaction mixture was dissolved in hot acetonitrile. The catalyst was removed by filtration and the filtrate cooled to 0°. The precipitated white solid product was filtered off and dried under vacuum. This title material (12.55 g) was used without further purification.

後処理

  1. customThe catalyst was removed by filtration
  2. temperaturethe filtrate cooled to 0°
  3. filtrationThe precipitated white solid product was filtered off
  4. customdried under vacuum
  5. customThis title material (12.55 g) was used without further purification

出典と根拠

ORDレコード
ord-967a8841842a4e9b886f3c2557540166
出典データセット
uspto-grants-1989_04
特許番号
US04822775

関連ノート

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