3-Morpholino-5-nitropyridin-4-amine → 5-Morpholinopyridine-3,4-diamine

HRID 62095ノート

反応式

HRID 62095 の反応式
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:8]=[N:9][CH:10]=[C:11]([N+:14]([O-])=O)[C:12]=2[NH2:13])[CH2:3][CH2:2]1>CO.[Pd]>[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[C:12]([NH2:13])=[C:11]([NH2:14])[CH:10]=[N:9][CH:8]=2)[CH2:3][CH2:2]1

参加物

4

反応物 1

HCID 583779133-Morpholino-5-nitropyridin-4-amine

生成物 1

HCID 583779865-Morpholinopyridine-3,4-diamine収率 37%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 3-morpholino-5-nitropyridin-4-amine (LIII) (1 eq) in MeOH was added 10% Pd/C. The solution was purged with hydrogen and stirred overnight at r.t. under hydrogen. The suspension was filtered through Celite and concentrated under vacuum to produce 5-morpholinopyridine-3,4-diamine (LIV) as a purple solid (37% yield). 1H NMR (DMSO-d6, 400 MHz,): δ 3.09-3.11 (m, 4H), 3.64-3.66 (m, 4H), 3.92 (s, 2H), 5.23 (s, 2H), 6.94 (s, 1H), 7.33 (s, 1H). ESIMS found C9H14N4O m/z 195 (M+H).

後処理

  1. customThe solution was purged with hydrogen
  2. filtrationThe suspension was filtered through Celite
  3. concentrationconcentrated under vacuum

出典と根拠

ORDレコード
ord-73a87f4ce8a042c698578c0f6d991e2b
出典データセット
uspto-grants-2016_09
特許番号
US09446035B2

反応ノート

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