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Methyl isothiocyanate → N-Methyl-N'-(4,4-dimethyl-1,2,3,4-tetrahydro-1,3-dioxo-7-isoquinolinyl)-thiourea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl isothiocyanate | HCID 11167 | — |
| 反応物 | 7-amino-4,4-dimethylisoquinoline-1,3(2H,4H)-dione | HCID 13558151 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | N-Methyl-N'-(4,4-dimethyl-1,2,3,4-tetrahydro-1,3-dioxo-7-isoquinolinyl)-thiourea | HCID 21242849 | — |
反応手順
1.3 g. (6.3 mmol) 7-Amino-4,4-dimethyl-isoquinolin-1,3-dione were dissolved in 30 ml. chloroform, mixed with 1.4 g. methyl isothiocyanate and boiled under reflux for 6 hours. The reaction mixture was then cooled and the precipitate was filtered off with suction and recrystallised from ethanol. Yield: 0.8 g. (46% of theory); m.p. 206°-207° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04824835 |
| 出典データセット | uspto-grants-1989_04 |
| ORD ID | ord-92272c8f848e4bf7884f58dfbe690085 |
| 出典メモ | uspto-grants-1989_04 |