Acetic Anhydride → HCID 21243163、化合物

HRID 621425

反応式

HRID 621425 の反応式
[NH2:1][C:2]1[N:7]=[C:6]([NH2:8])[N:5]=[C:4]([NH:9][CH:10]2[CH2:12][CH2:11]2)[N:3]=1.C(N(CC)CC)C.[C:20](OC(=O)C)(=[O:22])[CH3:21]>O1CCCC1>[CH:10]1([NH:9][C:4]2[N:3]=[C:2]([NH:1][C:20](=[O:22])[CH3:21])[N:7]=[C:6]([NH2:8])[N:5]=2)[CH2:12][CH2:11]1

参加物

5

反応物 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 47866Cyromazine

生成物 1

HCID 21243163HCID 21243163、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a suspension of 49.8 g of 2,4-diamino-6-cyclopropylamino-1,3,5-triazine and 45.5 g of triethylamine in 1200 ml of tetrahydrofuran are slowly added dropwise, at about 60° C. (in about 6 hours), 31.7 g of acetic acid anhydride dissolved in 100 ml of tetrahydrofuran. The reaction mixture is subsequently refluxed for 18 hours, filtered hot and then concentrated by evaporation until crystallisation commences. After the addition of about 300 ml of diethyl ether, the product if filtered off as white crystalline powder. It has a melting point of 190°-195° C.

後処理

  1. temperatureThe reaction mixture is subsequently refluxed for 18 hours
  2. filtrationfiltered hot
  3. concentrationconcentrated by evaporation until crystallisation commences
  4. additionAfter the addition of about 300 ml of diethyl ether
  5. filtrationthe product if filtered off as white crystalline powder

出典と根拠

ORDレコード
ord-6b903e07e5bc49d982a83da5f239842c
出典データセット
uspto-grants-1989_04
特許番号
US04824845

関連ノート

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