Ethanol → 2-(3-Bromo-5-methoxyphenyl)acetic acid

HRID 621451ノート

反応式

HRID 621451 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([O:11][CH3:12])[CH:5]=[C:6](CC#N)[CH:7]=1.[OH-:13].[Na+].[CH2:15]([OH:17])[CH3:16]>>[Br:1][C:2]1[CH:3]=[C:4]([O:11][CH3:12])[CH:5]=[C:6]([CH2:16][C:15]([OH:13])=[O:17])[CH:7]=1

参加物

4

反応物 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 212429652-(3-Bromo-5-methoxyphenyl)acetonitrile

生成物 1

HCID 212429042-(3-Bromo-5-methoxyphenyl)acetic acid

実験手順

A mixture of 5-bromo-3-methoxyphenylacetonitrile (22.6 g, 0.1 m) and 10% aqueous sodium hydroxide (300 ml) in ethanol (225 ml) is heated to 95° for 18 hours. The mixture is concentrated in vacuo, acidified with 10% hydrochloric acid and extracted with ethyl acetate. The ethyl acetate extract is washed, dried with sodium sulfate and concentrated in vacuo to give 5-bromo-3-methoxyphenylacetic acid.

後処理

  1. temperatureis heated to 95° for 18 hours
  2. concentrationThe mixture is concentrated in vacuo
  3. extractionextracted with ethyl acetate
  4. extractionThe ethyl acetate extract
  5. washis washed
  6. dry with materialdried with sodium sulfate
  7. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-f8d8aac79f9944a39050130b8f950566
出典データセット
uspto-grants-1989_04
特許番号
US04824839

反応ノート

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