1,2,3,4-Tetrahydro[1]benzothieno[2,3-c]pyridine → 2-[4-(3-Indolyl)butyl]-1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridine

HRID 621577

反応式

HRID 621577 の反応式
Cl[CH2:2][CH2:3][CH2:4][CH2:5][C:6]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[NH:8][CH:7]=1.BrCCCCC1C2C(=CC=CC=2)NC=1.[CH2:29]1[C:34]2[S:35][C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=3[C:33]=2[CH2:32][CH2:31][NH:30]1>C(#N)C>[NH:8]1[C:9]2[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=2)[C:6]([CH2:5][CH2:4][CH2:3][CH2:2][N:30]2[CH2:31][CH2:32][C:33]3[C:37]4[CH:38]=[CH:39][CH:40]=[CH:41][C:36]=4[S:35][C:34]=3[CH2:29]2)=[CH:7]1

参加物

5

反応物 3

HCID 4132821,2,3,4-Tetrahydro[1]benzothieno[2,3-c]pyridineHCID 133270113-(4-Chlorobutyl)indoleHCID 142011793-(4-Bromobutyl)-1h-indole

生成物 1

HCID 137474862-[4-(3-Indolyl)butyl]-1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridine

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A solution of 20.8 g of 3-(4-chlorobutyl)indole [or 25.2 g of 3-(4-bromobutyl)indole] and 18.9 g of 1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridine in 100 ml of acetonitrile is stirred at 20° for 12 hours. The usual working up is carried out, and 2-[4-(3-indolyl)butyl]-1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridine ("A"), m.p. 113°-115° is obtained.

出典と根拠

ORDレコード
ord-5bc875a47a0045b8af9f63d8a3e1b696
出典データセット
uspto-grants-1989_04
特許番号
US04824852

関連ノート

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