Acetyl chloride → N-[2-(Acetyloxy)ethyl]-N,N-dimethyldodecan-1-aminium bromide

HRID 621607ノート

反応式

HRID 621607 の反応式
[Br-:1].[CH2:2]([N+:14]([CH3:19])([CH3:18])[CH2:15][CH2:16][OH:17])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13].C(=O)([O-])[O-].[Na+].[Na+].[C:26](Cl)(=[O:28])[CH3:27]>CC(C)=O>[Br-:1].[CH2:2]([N+:14]([CH3:19])([CH3:18])[CH2:15][CH2:16][O:17][C:26](=[O:28])[CH3:27])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13]

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 10340Sodium CarbonateHCID 814861-Dodecanaminium, N-(2-hydroxyethyl)-N,N-dimethyl-, bromide (1:1)

生成物 1

HCID 13914766N-[2-(Acetyloxy)ethyl]-N,N-dimethyldodecan-1-aminium bromide

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

反応条件

温度
60 °C

実験手順

In a reaction vessel was placed 13.14 grams of dodecyl dimethyl 2-hydroxyethyl ammonium bromide, 21.22 grams of acetone solvent and 4.72 grams of sodium carbonate. While stirring under nitrogen, 3.27 grams of acetyl chloride was added dropwise. Gas evolution occurred. The mixture was then refluxed (approx. 60° C.) for 6 hours. The solvent was removed under vacuum. The residue was extracted with isopropanol to dissolve the quat and the solution was filtered hot to removed sodium chloride and sodium carbonate. The filtrate was evaporated under vacuum leaving as the product dodecyl dimethyl acetyloxyethyl ammonium bromide.

後処理

  1. customIn a reaction vessel was placed
  2. customThe solvent was removed under vacuum
  3. extractionThe residue was extracted with isopropanol
  4. dissolutionto dissolve the quat
  5. filtrationthe solution was filtered hot
  6. customto removed sodium chloride and sodium carbonate
  7. customThe filtrate was evaporated under vacuum

出典と根拠

ORDレコード
ord-ad80dc4138404862b21d909f7f27b461
出典データセット
uspto-grants-1989_04
特許番号
US04824867

反応ノート

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