Thionyl Chloride → 1-Chloromethyl-3-methyl-4-phenylthiobenzene

HRID 621640ノート

反応式

HRID 621640 の反応式
O[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:5]([CH3:16])[CH:4]=1.S(Cl)([Cl:19])=O>C(Cl)Cl>[Cl:19][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([S:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[C:5]([CH3:16])[CH:4]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 19934635HCID 19934635、化合物

生成物 1

HCID 199346681-Chloromethyl-3-methyl-4-phenylthiobenzene

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The 1-hydroxymethyl-3-methyl-4-phenylthiobenzene obtained above is dissolved in methylene chloride (100 ml), and thereto is added with stirring thionyl chloride (23.34 ml) under ice cooling. The mixture is stirred for one hour, and the reaction mixture is washed with ice water (100 ml×3), and thereto is added ethyl acetate (500 ml). The mixture is washed in order with 5% aqueous sodium hydrogen carbonate solution (50 ml×4) and saturated aqueous sodium chloride solution (100 ml×2), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 1-chloromethyl-3-methyl-4-phenylthiobenzene.

後処理

  1. washthe reaction mixture is washed with ice water (100 ml×3)
  2. additionis added ethyl acetate (500 ml)
  3. washThe mixture is washed in order with 5% aqueous sodium hydrogen carbonate solution (50 ml×4) and saturated aqueous sodium chloride solution (100 ml×2)
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-2e1f63cb9aee473eb492836264b4855e
出典データセット
uspto-grants-1989_04
特許番号
US04824834

反応ノート

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