Methyl iodide → 1-Methyl-3-{N-[beta-(4-hydroxyphenyl)ethyl]}carbamoylpyridinium iodide
反応式
[C:1]([NH:9][CH2:10][CH2:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.[CH3:19][I:20]>CC(C)=O>[I-:20].[CH3:19][N+:4]1[CH:5]=[CH:6][CH:7]=[C:2]([C:1](=[O:8])[NH:9][CH2:10][CH2:11][C:12]2[CH:13]=[CH:14][C:15]([OH:18])=[CH:16][CH:17]=2)[CH:3]=1参加物
4
実験手順
To a solution of 1.21 g (5 mmol) of nicotinoyltyramine in 10 ml of acetone, 1.41 g (10 mmol) of methyl iodide were added and the mixture was refluxed while stirring for 6 hrs. The fine, yellow solid which separated was filtered and crystallized from methanol ether. Yield 1.78 g (93%), m.p. 208°-210° C. PMR (DMSO-d6 /D2O) δ 9.23-8.26 (m, 4H, C5H4N+), 7.33-6.83 (m, 4H, C6H4), 4.50 (s, 3H, ##STR1537## 3.70 (t, J=7 Hz, 2H, ##STR1538## 2.93 (t, J=7 Hz, 2H, CH2).