Hydrochloric Acid → 2-Acetyl-4-methoxycyclohexanone

HRID 621710

反応式

HRID 621710 の反応式
[H-].[Na+].[C:3](OCC)(=[O:5])[CH3:4].[CH3:9][O:10][CH:11]1[CH2:16][CH2:15][C:14](=[O:17])[CH2:13][CH2:12]1.Cl>O.CO.C1C=CC=CC=1>[C:3]([CH:15]1[CH2:16][CH:11]([O:10][CH3:9])[CH2:12][CH2:13][C:14]1=[O:17])(=[O:5])[CH3:4]

参加物

8

反応物 4

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 24758Sodium hydride2 回HCID 5350284-Methoxycyclohexanone

生成物 1

HCID 136327242-Acetyl-4-methoxycyclohexanone

試薬・触媒・溶媒 3

HCID 241Benzene溶媒HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

1.12 g of 60% sodium hydride was added to 2.5 g of ethyl acetate and 1.78 g of a benzene solution of 4-methoxycyclohexanone was added thereto. After reacting at 40° C. for three hours, methanol was added to thereby decompose excessive sodium hydride and the reaction mixture was poured into water, neutralized with hydrochloric acid and extracted with ether to give 1.02 g of 2-acetyl4-methoxycyclohexanone. NMRδTMSCCl4 : 2.06 (3H, s). 1.7-2.5 (8H, s), 3.28 (3H , s), 3.4 (1H, m) and 15.9 (1H, s).

後処理

  1. additionwas added
  2. extractionextracted with ether

出典と根拠

ORDレコード
ord-4cb7820e2c0d4756ac91ec0260e9fb9c
出典データセット
uspto-grants-1989_04
特許番号
US04824952

関連ノート

読み込み中…