Ethyl Acetoacetate → Methyl 3-hydroxy-5-methylthiophene-2-carboxylate

HRID 621783ノート

反応式

HRID 621783 の反応式
[C:1]([O:7][CH2:8]C)(=[O:6])[CH2:2][C:3]([CH3:5])=[O:4].[C:10](OC)(=O)[CH2:11][SH:12].[Na]>ClCCl>[OH:4][C:3]1[CH:5]=[C:11]([CH3:10])[S:12][C:2]=1[C:1]([O:7][CH3:8])=[O:6]

参加物

5

反応物 3

HCID 8868Ethyl AcetoacetateHCID 16907Methyl ThioglycolateHCID 5360545Sodium

生成物 1

HCID 587860Methyl 3-hydroxy-5-methylthiophene-2-carboxylate収率 52.3%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Prepared by the method described in Example 1 from ethyl acetoacetate (130 g, 1.0 mole), methyl thioglycolate (212 g, 2.0 moles) and sodium (53 g, 2.3 moles). The crude product is shaken with two portions of dichloromethane, filtered, and the filtrate stripped of solvent under reduced pressure to afford the product (90.1 g); mp 50°-53° C.

後処理

  1. customPrepared by the method
  2. filtrationfiltered

出典と根拠

ORDレコード
ord-a0d5afd534c549998c46e0ca23cb59e2
出典データセット
uspto-grants-1989_04
特許番号
US04824958

反応ノート

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