Iodine → 2-Amino-4-(4-methoxyphenyl)thiazole

HRID 622059

反応式

HRID 622059 の反応式
[NH2:1][C:2]([NH2:4])=[S:3].[CH3:5][C:6]([C:8]1[CH:13]=[CH:12][C:11]([O:14][CH3:15])=[CH:10][CH:9]=1)=O.II>>[CH3:15][O:14][C:11]1[CH:12]=[CH:13][C:8]([C:6]2[N:1]=[C:2]([NH2:4])[S:3][CH:5]=2)=[CH:9][CH:10]=1

参加物

4

反応物 3

HCID 807IodineHCID 74764'-MethoxyacetophenoneHCID 2723790Thiourea

生成物 1

HCID 1596442-Amino-4-(4-methoxyphenyl)thiazole収率 91.7%

実験手順

33.5 g of thiourea are added to 30 g of 4-methoxyacetophenone, 56 g of iodine are added and the mixture is kept at 100° C. for 5 hours. The reaction mixture is discharged onto water, powdered, washed several times with ether then with ammonia solution and finally with water, and dried. 37.8 g of 4-(4-methoxyphenyl)-thiazol-2-yl-amine of melting point 194°-205° C. are obtained.

後処理

  1. additionare added
  2. washwashed several times with ether
  3. dry with materialwith ammonia solution and finally with water, and dried

出典と根拠

ORDレコード
ord-09dba717f1474456a3f92a8f3ab1376d
出典データセット
uspto-grants-1988_09
特許番号
US04769062

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