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Diisopropylcarbodiimide → 1,3-Dipropyl-8-(2-amino-4-chlorophenyl)xanthine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylcarbodiimide | HCID 12734 | — |
| 反応物 | 4-Chloro-2-nitrobenzoic acid | HCID 80475 | — |
| 反応物 | 6-Amino-5-nitroso-1,3-dipropylpyrimidine-2,4(1H,3H)-dione | HCID 5182018 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 1,3-Dipropyl-8-(2-amino-4-chlorophenyl)xanthine | HCID 92411 | 2.1% |
反応手順
1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine was synthesized by a modification of the method of Pfleiderer and Kempter (Ang. Int. Ed. 6:259-260, 1967). 2-nitro-4-chlorobenzoic acid (0.02 mol) was dissolved in 30 ml of methanol. 1,3-dipropyl-5-nitroso-6-aminouracil (0.01 mol) was added with stirring, followed by 0.2 mol diisopropylcarbodiimide (DICD).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04769377 |
| 出典データセット | uspto-grants-1988_09 |
| ORD ID | ord-1add9e0fb7954945a3db6f4e30e8a4ee |
| 出典メモ | uspto-grants-1988_09 |