Water → 6-Bromo-2-[2-(diisopropylamino)ethyl]phthalazin-1(2H)-one

HRID 622124

反応式

HRID 622124 の反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[NH:7][N:6]=[CH:5]2.[OH-].[K+].Cl.[CH:16]([N:19]([CH:23]([CH3:25])[CH3:24])[CH2:20][CH2:21]Cl)([CH3:18])[CH3:17].O>CS(C)=O>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](=[O:12])[N:7]([CH2:21][CH2:20][N:19]([CH:23]([CH3:25])[CH3:24])[CH:16]([CH3:18])[CH3:17])[N:6]=[CH:5]2

参加物

6

反応物 4

HCID 962WaterHCID 14797Potassium HydroxideHCID 779422-Chloroethyldiisopropylammonium chlorideHCID 115359186-Bromophthalazin-1(2h)-one

生成物 1

HCID 212933346-Bromo-2-[2-(diisopropylamino)ethyl]phthalazin-1(2H)-one

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

6-Bromophthalazinone (11.2 gm, 0.05 mole) was slurried in 80 ml dimethylsulfoxide. To this was added 22 ml 45% KOH (0.25 mole). After stirring 10 minutes 16 gm 2-(diisopropylamino)ethyl chloride hydrochloride was added and the mixture stirred for 18 hours. A water bath was used to moderate the slightly exothermic reaction (temperature <=25°). Water (100 ml) was added to the reaction mixture, which was then stirred another hour.

後処理

  1. additionwas added
  2. customA water bath was used
  3. customthe slightly exothermic reaction (temperature <=25°)
  4. stirringwas then stirred another hour

出典と根拠

ORDレコード
ord-8beea11fd514416690c0bd6c6de67784
出典データセット
uspto-grants-1988_09
特許番号
US04769369

関連ノート

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