Methyl iodide → HCID 88521502、化合物

HRID 622315

反応式

HRID 622315 の反応式
[CH3:1][CH2:2][O:3][C:4]([C:6]1[N:10]([CH:11]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH3:12])[CH:9]=[N:8][CH:7]=1)=[O:5].[I:19][CH3:20]>ClCCl>[I-:19].[CH2:2]([O:3][C:4]([C:6]1[NH+:10]([CH:11]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH3:12])[CH2:9][N:8]([CH3:20])[CH:7]=1)=[O:5])[CH3:1]

参加物

4

反応物 2

HCID 6328Methyl iodideHCID 36339Ethnor

生成物 1

HCID 88521502HCID 88521502、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of 7 parts of R-(+) ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate in 19.5 parts of iodomethane were added 21.3 parts of dichloromethane and the whole was stirred for 24 hours at room temperature. The reaction mixture was evaporated and the residue was crystallized from 2-propanol. The product was filtered off and washed with petroleum ether, yielding 7.03 parts of 5-ethoxycarbonyl-3-methyl-1-(1-phenylethyl)-1H-imidazolium iodide; mp. 159.5° C.; [α]D =-62.79° (10% water).

後処理

  1. customThe reaction mixture was evaporated
  2. customthe residue was crystallized from 2-propanol
  3. filtrationThe product was filtered off
  4. washwashed with petroleum ether

出典と根拠

ORDレコード
ord-47aabe38e2c64e22973abf66b181e665
出典データセット
uspto-grants-1988_09
特許番号
US04770689

関連ノート

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