Methanol → HCID 178501206、化合物

HRID 623383ノート

反応式

HRID 623383 の反応式
[NH2:1][C@@H:2]1[CH2:7][CH2:6][C@H:5]([C:8]([OH:10])=[O:9])[CH2:4][CH2:3]1.O=S(Cl)Cl.[CH3:15]O>>[NH2:1][C@@H:2]1[CH2:7][CH2:6][C@H:5]([C:8]([O:10][CH3:15])=[O:9])[CH2:4][CH2:3]1

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 178511566HCID 178511566、化合物

生成物 1

HCID 178501206HCID 178501206、化合物

実験手順

A suspension of cis-4-aminocyclohexanecarboxylic acid (5.0 g, 34.9 mmol) in methanol (50 mL) was stirred at room temperature and SOCl2 (7.1 mL, 98.4 mmol) was added dropwise over 20 minutes, causing the solid to dissolve. The solution was stirred overnight and the methanol was then removed under reduced pressure. The residual solid was triturated with diethyl ether and air-dried and the title compound obtained as an off-white powder (6.0 g).

後処理

  1. dissolutionto dissolve
  2. stirringThe solution was stirred overnight
  3. customthe methanol was then removed under reduced pressure
  4. customThe residual solid was triturated with diethyl ether
  5. customair-dried

出典と根拠

ORDレコード
ord-3d2293090a614a479efad5ab4c8a7327
出典データセット
uspto-grants-2016_04
特許番号
US09302984B2

反応ノート

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