Hydrochloric Acid → 2-(Ethylcarbamoyl)isonicotinic acid
反応式
[CH2:1]([NH:3][C:4]([C:6]1[CH:7]=[C:8]([CH:13]=[CH:14][N:15]=1)[C:9]([O:11]C)=[O:10])=[O:5])[CH3:2].[OH-].[Na+].Cl>CO>[CH2:1]([NH:3][C:4]([C:6]1[CH:7]=[C:8]([CH:13]=[CH:14][N:15]=1)[C:9]([OH:11])=[O:10])=[O:5])[CH3:2]参加物
5
実験手順
A mixture of methyl 2-(ethylcarbamoyl)isonicotinate (520 mg, 2.50 mmol, Step-1), 2M aqueous sodium hydroxide solution (2.5 mL), and methanol (6 mL) is stirred at room temperature for 3 hours. After addition of 2M hydrochloric acid (2.5 mL), the solvent is removed by evaporation. The residue is suspended in THF (20 mL), and the mixture is filtered through a pad of Celite. The filtrate is concentrated in vacuo to give 491 mg (quantitative yield) of the title compound as a white solid.
後処理
- customthe solvent is removed by evaporation
- filtrationthe mixture is filtered through a pad of Celite
- concentrationThe filtrate is concentrated in vacuo
出典と根拠
- ORDレコード
- ord-b8a757b94a96408db3df704dd6873bf1
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09302991B2
反応ノート
読み込み中…