HCID 86704207、化合物 → 1-[2-(4,6-Dimethoxy-pyrimidin-2-yloxy)-ethyl]-1H-pyrazol-4-ylamine

HRID 624013ノート

反応式

HRID 624013 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([O:11][CH2:12][CH2:13][N:14]2[CH:18]=[C:17]([N+:19]([O-])=O)[CH:16]=[N:15]2)[N:4]=1>CCOC(C)=O.CCO.O=[Pt]=O>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[N:4]=[C:5]([O:11][CH2:12][CH2:13][N:14]2[CH:18]=[C:17]([NH2:19])[CH:16]=[N:15]2)[N:6]=1

参加物

5

反応物 1

HCID 86704207HCID 86704207、化合物

生成物 1

HCID 682827731-[2-(4,6-Dimethoxy-pyrimidin-2-yloxy)-ethyl]-1H-pyrazol-4-ylamine

試薬・触媒・溶媒 3

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒2 回HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 4,6-dimethoxy-2-(2-(4-nitro-1H-pyrazol-1-yl)ethoxy)pyrimidine (2.05 g, 6.93 mmol), in EtOAc (3.0 mL, degassed) and EtOH (9 mL, degassed), PtO2 (135 mg, 0.70 mmol) was added and the reaction mixture was stirred at rt under a H2-atmosphere for 3 h. The mixture was diluted with EtOH, filtered over celite and the filter cake was rinsed with EtOH. The filtrate was concentrated to obtain the title compound as a red oil. LC-MS conditions A: tR=0.58 min, [M+H]+=266.02.

後処理

  1. filtrationfiltered over celite
  2. washthe filter cake was rinsed with EtOH
  3. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-1c04a8914b4b45e5958600a82c0491af
出典データセット
uspto-grants-2016_04
特許番号
US09303023B2

反応ノート

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