1-[3-(2,3-Dihydro-indol-1-yl)-propyl]-1H-pyrazol-4-ylamine → 1-(3-Indol-1-yl-propyl)-1H-pyrazol-4-ylamine

HRID 624024ノート

反応式

HRID 624024 の反応式
[N:1]1([CH2:10][CH2:11][CH2:12][N:13]2[CH:17]=[C:16]([NH2:18])[CH:15]=[N:14]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH2:2]1>CC(C)=O.O=[Mn]=O>[N:1]1([CH2:10][CH2:11][CH2:12][N:13]2[CH:17]=[C:16]([NH2:18])[CH:15]=[N:14]2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH:3]=[CH:2]1

参加物

4

反応物 1

HCID 682827791-[3-(2,3-Dihydro-indol-1-yl)-propyl]-1H-pyrazol-4-ylamine

生成物 1

HCID 682831811-(3-Indol-1-yl-propyl)-1H-pyrazol-4-ylamine

試薬・触媒・溶媒 2

HCID 14801Manganese dioxide触媒HCID 180Acetone溶媒2 回

実験手順

A solution of 1-[3-(2,3-dihydro-indol-1-yl)-propyl]-1H-pyrazol-4-ylamine (200 mg, 0.83 mmol) in acetone (1.0 mL) was added dropwise to a suspension of MnO2 (275 mg, 3.17 mmol) in acetone (2.0 mL). The resulting dark reaction mixture was stirred at rt overnight, then filtered over celite, washed with acetone and the solvent was removed under reduced pressure to yield the title compound which was used without further purification in the next step. LC-MS conditions B: tR=0.51 min, [M+H]+=241.20.

後処理

  1. customThe resulting dark reaction mixture
  2. filtrationfiltered over celite
  3. washwashed with acetone
  4. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-8fe1a24413b2403da50ad27fd985e3ea
出典データセット
uspto-grants-2016_04
特許番号
US09303023B2

反応ノート

読み込み中…