1-(2-(4-nitro-1H-pyrazol-1-yl)ethyl)indoline → 1-(2-(Indolin-1-yl)ethyl)-1H-pyrazol-4-amine

HRID 624037ノート

反応式

HRID 624037 の反応式
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([CH2:9][CH2:10][N:11]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:13][CH2:12]2)[CH:8]=1)([O-])=O>CCOC(C)=O.CCO.O=[Pt]=O>[N:11]1([CH2:10][CH2:9][N:7]2[CH:8]=[C:4]([NH2:1])[CH:5]=[N:6]2)[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH2:13][CH2:12]1

参加物

5

反応物 1

HCID 682835761-(2-(4-nitro-1H-pyrazol-1-yl)ethyl)indoline

生成物 1

HCID 621388071-(2-(Indolin-1-yl)ethyl)-1H-pyrazol-4-amine

試薬・触媒・溶媒 3

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒2 回HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 1-(2-(4-nitro-1H-pyrazol-1-yl)ethyl)indoline (183 mg, 0.71 mmol) in EtOAc (0.7 mL, degassed) and EtOH (2 mL, degassed), PtO2 (14 mg, 0.07 mmol) was added and the reaction mixture was stirred at rt under a H2-atmosphere for 18 h. The mixture was diluted with EtOH, filtered over celite and the filter cake was rinsed with EtOH. The filtrate was concentrated to obtain the title compound as an oil, which was used in the next step without further purification. LC-MS conditions A: tR=0.51 min, [M+H]+=229.26.

後処理

  1. filtrationfiltered over celite
  2. washthe filter cake was rinsed with EtOH
  3. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-9580a8ee934d42178a693706bf38d015
出典データセット
uspto-grants-2016_04
特許番号
US09303023B2

反応ノート

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