2-(4-Nitro-1H-pyrazol-1-yl)ethan-1-ol → 2-(4-Amino-1H-pyrazol-1-yl)ethanol

HRID 624062ノート

反応式

HRID 624062 の反応式
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([CH2:9][CH2:10][OH:11])[CH:8]=1)([O-])=O>CCOC(C)=O.CCO.O=[Pt]=O>[NH2:1][C:4]1[CH:5]=[N:6][N:7]([CH2:9][CH2:10][OH:11])[CH:8]=1

参加物

5

反応物 1

HCID 1620552-(4-Nitro-1H-pyrazol-1-yl)ethan-1-ol

生成物 1

HCID 284922672-(4-Amino-1H-pyrazol-1-yl)ethanol

試薬・触媒・溶媒 3

HCID 345198Adams' catalyst触媒HCID 702Ethanol溶媒2 回HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 2-(4-nitro-1H-pyrazol-1-yl)ethanol (9.12 g, 58.07 mmol) in EtOAc (20 mL, degassed) and EtOH (60 mL, degassed), PtO2 (1.13 g, 5.81 mmol) was added and the reaction mixture was stirred at rt under a H2-atmosphere for 18 h. The mixture was diluted with EtOH, filtered over celite and the filter cake was rinsed with EtOH. The filtrate was concentrated to obtain 2-(4-amino-1H-pyrazol-1-yl)ethanol as a red oil, which was used in the next step without further purification. LC-MS conditions A: tR=0.14 min, [M+H]+=128.24.

後処理

  1. filtrationfiltered over celite
  2. washthe filter cake was rinsed with EtOH
  3. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-5bcd7949ce0149e5889458edf52f2fa9
出典データセット
uspto-grants-2016_04
特許番号
US09303023B2

反応ノート

読み込み中…