2-Amino-1-methylbenzimidazole → N-(1-(2-((1-methyl-1H-benzo[d]imidazol-2-yl)amino)ethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide

HRID 624087

反応式

O=[CH:2][CH2:3][N:4]1[CH:8]=[C:7]([NH:9][C:10]([C:12]2[N:13]=[CH:14][O:15][C:16]=2[C:17]2[CH:18]=[C:19]([CH3:23])[CH:20]=[CH:21][CH:22]=2)=[O:11])[CH:6]=[N:5]1.[CH3:24][N:25]1[C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=2[N:27]=[C:26]1[NH2:34]>CC#N.C(Cl)Cl.CC(O)=O>[CH3:24][N:25]1[C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=2[N:27]=[C:26]1[NH:34][CH2:2][CH2:3][N:4]1[CH:8]=[C:7]([NH:9][C:10]([C:12]2[N:13]=[CH:14][O:15][C:16]=2[C:17]2[CH:18]=[C:19]([CH3:23])[CH:20]=[CH:21][CH:22]=2)=[O:11])[CH:6]=[N:5]1

参加物

実験手順

To a solution of N-(1-(2-oxoethyl)-1H-pyrazol-4-yl)-5-(m-tolyl)oxazole-4-carboxamide (157 mg, 0.45 mmol) in MeCN (1 mL) and DCM (0.8 mL) was added 1-methyl-1H-benzo[d]imidazol-2-amine (66 mg, 0.45 mmol) followed by STAB (190 mg, 0.90 mmol) and 1 drop of AcOH. After stirring at rt for 18 h, the reaction mixture was filtered and directly purified by prep. HPLC. LC-MS conditions D: tR=0.77 min, [M+H]+=442.3.

後処理

filtrationthe reaction mixture was filtered
customdirectly purified by prep

出典と根拠

ORDレコード: ord-9130f2bea5f74ed7b99ecb02a1f04190
出典データセット: uspto-grants-2016_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09303023B2

反応式

参加物

反応物 2

生成物 1

試薬・触媒・溶媒 3

実験手順

後処理

出典と根拠

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