3-Hydroxybenzaldehyde → 3-(Dimethylaminomethyl)phenol

HRID 624328

反応式

HRID 624328 の反応式
[OH:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=O.[CH3:10][NH:11][CH3:12].C(O[BH-](OC(=O)C)OC(=O)C)(=O)C.[Na+].CO>C1COCC1.C(Cl)Cl>[CH3:10][N:11]([CH2:5][C:4]1[CH:3]=[C:2]([OH:1])[CH:9]=[CH:8][CH:7]=1)[CH3:12]

参加物

7

反応物 4

HCID 1013-HydroxybenzaldehydeHCID 674DimethylamineHCID 887MethanolHCID 5049666Sodium triacetoxyborohydride

生成物 1

HCID 328963-(Dimethylaminomethyl)phenol

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

3-Hydroxybenzaldehyde (1.0 g), 2M dimethylamine in THF (5 mL), and sodium triacetoxyborohydride (2 g) in CH2Cl2 (10 mL) were stirred for 24 hours. The mixture was treated with methanol and chromatographed on silica gel with 2-25% ethyl acetate/hexanes.

後処理

  1. customchromatographed on silica gel with 2-25% ethyl acetate/hexanes

出典と根拠

ORDレコード
ord-fb8d2162ac9c4c14a6d8c52ea581c100
出典データセット
uspto-grants-2016_04
特許番号
US09303025B2

関連ノート

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