1-Methyl-1,5,6,7-tetrahydro-4H-indazol-4-one → 1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-ol

HRID 62440

反応式

HRID 62440 の反応式
[CH3:1][N:2]1[C:10]2[CH2:9][CH2:8][CH2:7][C:6](=[O:11])[C:5]=2[CH:4]=[N:3]1.[BH4-].[Na+]>CCO>[CH3:1][N:2]1[C:10]2[CH2:9][CH2:8][CH2:7][CH:6]([OH:11])[C:5]=2[CH:4]=[N:3]1

参加物

4

反応物 2

HCID 27657961-Methyl-1,5,6,7-tetrahydro-4H-indazol-4-oneHCID 4311764Sodium borohydride

生成物 1

HCID 138368981-methyl-4,5,6,7-tetrahydro-1H-indazol-4-ol収率 68.8%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of 1-methyl-6,7-dihydro-1H-indazol-4(5H)-one (1 g, 6.7 mmol) in EtOH (20 mL) was added NaBH4 (1.2 g, 33.3 mmol) in portions. The resulting mixture was stirred at room temperature for 30 min. The solvent was removed under reduced pressure to afford the crude 1-methyl-4,5,6,7-tetrahydro-1H-indazol-4-ol (700 mg, 68.8%), which was used in the next step directly. MS-ESI (m/z): 153 (M+1)+ (Acq Method: 10-80AB_2 min_220 &254.1 cm; Rt: 0.17 min)

後処理

  1. customThe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-c9ed543f7ed5432c8ce38d7841ae8fe8
出典データセット
uspto-grants-2016_09
特許番号
US09446130B2

関連ノート

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