2-Amino-4-chlorobenzoic acid → (2-Amino-4-chlorophenyl)methanol

In a 500 mL round bottom flask, the stirred solution of 2-amino-4-chlorobenzoic acid (42.8 g, 250.29 mmol, Aldrich) was dissolved anhydrous THF (200 mL) and the solution was cooled in an ice-bath. Lithium aluminum hydride (11.76 g, 312.86 mmol) was added portionwise to the above solution at the ice-bath temperature under nitrogen atmosphere. The resulting mixture was stirred at rt for 8 h. On completion of reaction the reaction mixture was cooled to ice-bath temperature and quenched by sequential addition of cold water (12 mL), 15% NaOH (12 mL) and water (36 mL). The resulting slurry was stirred at rt for 30 min and filtered through a CELITE™ pad. The solid residue was washed with ethyl acetate (1000 mL) and combined filtrate was concentrated under reduced pressure to give (2-amino 4-chlorophenyl)methanol as an off white solid. Yield: 32 g (81.6%). LCMS (ESI, m/z): 181 (M+23)+

1. temperaturethe solution was cooled in an ice-bath
2. customOn completion of reaction the reaction mixture
3. temperaturewas cooled to ice-bath temperature
4. customquenched by sequential addition of cold water (12 mL), 15% NaOH (12 mL) and water (36 mL)
5. stirringThe resulting slurry was stirred at rt for 30 min
6. filtrationfiltered through a CELITE™ pad
7. washThe solid residue was washed with ethyl acetate (1000 mL)
8. concentrationwas concentrated under reduced pressure

ORDレコード

ord-d6cfd940e3d04d2eadb145133f470105

出典データセット

uspto-grants-2016_04

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US09303028B2