5-Azido-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde → 5-Amino-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde

HRID 624832ノート

反応式

HRID 624832 の反応式
[N:1]([C:4]1[CH:9]=[C:8]([NH:10][CH:11]2[CH2:13][CH2:12]2)[N:7]2[N:14]=[CH:15][C:16]([CH:17]=[O:18])=[C:6]2[N:5]=1)=[N+]=[N-]>[Pd].C(O)C>[NH2:1][C:4]1[CH:9]=[C:8]([NH:10][CH:11]2[CH2:13][CH2:12]2)[N:7]2[N:14]=[CH:15][C:16]([CH:17]=[O:18])=[C:6]2[N:5]=1

参加物

4

反応物 1

HCID 866546625-Azido-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde

生成物 1

HCID 583137635-Amino-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde収率 85%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

The above product 5-azido-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde (1.09 g, 4.46 mmol) was subjected to hydrogenation using 10% wt palladium on carbon in ethanol. The reaction was stirred under hydrogen for 6 hours. The mixture was filtered through celite and sonicated with 1:1 mixture of ethyl acetate and hexane. The light yellow solid was filtered and dried to yield 5-amino-7-(cyclopropylamino)pyrazolo[1,5-a]pyrimidine-3-carbaldehyde as product 750 mg (85% yield). LCMS (M+1=218)

後処理

  1. filtrationThe mixture was filtered through celite
  2. customsonicated with 1:1 mixture of ethyl acetate and hexane
  3. filtrationThe light yellow solid was filtered
  4. customdried

出典と根拠

ORDレコード
ord-fd3287d797384144b105c872522746a1
出典データセット
uspto-grants-2016_04
特許番号
US09303033B2

反応ノート

読み込み中…