反応式
[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:17]([OH:19])=O)=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:16][CH2:15][CH2:14][O:13]2)[CH2:3][CH2:2]1.[CH3:20][C:21]1([CH3:27])[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1.CN(C(ON1N=NC2C=CC=CC1=2)=[N+](C)C)C.[B-](F)(F)(F)F.CCN(C(C)C)C(C)C>>[CH:1]1([C:4]2[CH:5]=[CH:6][C:7]([C:17]([N:24]3[CH2:25][CH2:26][C:21]([CH3:27])([CH3:20])[CH2:22][CH2:23]3)=[O:19])=[N:8][C:9]=2[O:10][CH2:11][CH:12]2[CH2:16][CH2:15][CH2:14][O:13]2)[CH2:2][CH2:3]1参加物
5
実験手順
In analogy to the procedure described in Example 47 b), 5-cyclopropyl-6-(tetrahydro-furan-2-ylmethoxy)-pyridine-2-carboxylic acid (Example 4 b)) was reacted with 4,4-dimethyl-piperidine (4045-30-1) in the presence of TBTU and DIEA to obtain the title compound as colorless oil; MS (EI): m/e=359.6 [MH+].
出典と根拠
- ORDレコード
- ord-e753ddb0df05463a8f8653aa23a82428
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09303012B2
関連ノート
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