Water → HCID 86664460、化合物
反応式
[CH2:1]=[CH:2][CH2:3][NH2:4].[CH2:5]1[O:7][CH:6]1[CH2:8][Cl:9].Cl.[OH-:11].[Na+].[OH2:13]>>[CH2:1]=[CH:2][CH2:3][NH3+:4].[CH2:5]1[O:7][CH:6]1[CH2:8][Cl:9].[C:5]([O-:7])([OH:13])=[O:11].[C:5](=[O:7])([OH:13])[O-:11]参加物
4
反応条件
- 温度
- 36 °C
実験手順
1.4 kg of water is loaded into a 2 liter glass reactor. The temperature is set to 35° C. and 100 g of sevelamer hydrochloride is added in portions, stirring the mixture. A solution of 30% sodium hydroxide is then added until pH 12 is reached (around 71 g). The suspension is maintained at 35-37° C. under stirring for 40 minutes and then filtered, the wet solid is resuspended in 800 ml of distilled water and stirred for two hours at room temperature. The solid is then filtered and washed with distilled water. The solid is loaded into a fluid bed dryer at 50° C. for three hours, after which a carbon dioxide stream is passed through the solid until obtaining an internal pressure of around 40000 Pa. The flow is maintained until the pressure decreases. Finally, the drier is maintained under vacuum and the temperature is raised to 60° C. for 72 hours. Sevelamer carbonate/bicarbonate is thus obtained.