1-(2-Hydroxyethyl)piperazine → HCID 57516914、化合物

HRID 62528ノート

反応式

HRID 62528 の反応式
F[C:2]1[CH:3]=[CH:4][C:5]([N+:12]([O-:14])=[O:13])=[C:6]([CH:11]=1)[C:7]([NH:9][CH3:10])=[O:8].[OH:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]1.CCN(C(C)C)C(C)C>CN(C=O)C>[OH:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][N:21]([C:2]2[CH:3]=[CH:4][C:5]([N+:12]([O-:14])=[O:13])=[C:6]([CH:11]=2)[C:7]([NH:9][CH3:10])=[O:8])[CH2:20][CH2:19]1

参加物

5

反応物 3

HCID 76771-(2-Hydroxyethyl)piperazineHCID 81531DiisopropylethylamineHCID 442030775-Fluoro-N-methyl-2-nitrobenzamide

生成物 1

HCID 57516914HCID 57516914、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

A solution of 5-fluoro-N-methyl-2-nitrobenzamide, 1-(2-hydroxyethyl)piperazine, and Hunig's base in 20 mL of DMF was stirred at room temperature over the weekend. The resulting mixture was rotavaped to dryness, and the residue was purified by flash column SF40-150 at 2%-10% MeOH/CH2Cl2. Product came out at 7% MeOH/CH2Cl2. MS(ES) m/e 309 [M+H].

後処理

  1. customthe residue was purified by flash column

出典と根拠

ORDレコード
ord-925e971aa562492cb85f444030df8fcd
出典データセット
uspto-grants-2016_09
特許番号
US09446034B2

反応ノート

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