2-Methoxyethylamine → 3-(benzyl(methyl)amino)-N-(2-methoxyethyl)propanamide

HRID 625358ノート

反応式

HRID 625358 の反応式
[CH2:1]([N:8]([CH3:15])[CH2:9][CH2:10][C:11]([O:13]C)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:16][O:17][CH2:18][CH2:19][NH2:20]>>[CH2:1]([N:8]([CH3:15])[CH2:9][CH2:10][C:11]([NH:20][CH2:19][CH2:18][O:17][CH3:16])=[O:13])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 80182-MethoxyethylamineHCID 824679Methyl 3-(benzyl(methyl)amino)propanoate

生成物 1

HCID 665868063-(benzyl(methyl)amino)-N-(2-methoxyethyl)propanamide収率 61%

反応条件

温度
100 °C

実験手順

To methyl 3-(benzyl(methyl)amino)propanoate (1.5 g, 7.24 mmol, 1.00 equiv) was added 2-methoxyethanamine (11 g, 146.45 mmol, 20.00 equiv) and the mixture was stirred for 2 days at 100° C. in sealed tube. The resulting mixture was concentrated under vacuum and purified via silica gel chromatography (dichloromethane/methanol 30:1) to afford 1.1 g (61%) of the product as a yellow oil.

後処理

  1. concentrationThe resulting mixture was concentrated under vacuum
  2. custompurified via silica gel chromatography (dichloromethane/methanol 30:1)

出典と根拠

ORDレコード
ord-6186aa193c764c50838079768310656a
出典データセット
uspto-grants-2016_04
特許番号
US09301951B2

反応ノート

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