3-(benzyl(methyl)amino)-N-(2-methoxyethyl)propanamide → N-(2-methoxyethyl)-3-(methylamino)propanamide

HRID 625359ノート

反応式

HRID 625359 の反応式
[CH2:1]([N:8](C)[CH2:9][CH2:10][C:11]([NH:13][CH2:14][CH2:15][O:16][CH3:17])=[O:12])C1C=CC=CC=1>CO.[Pd]>[CH3:17][O:16][CH2:15][CH2:14][NH:13][C:11](=[O:12])[CH2:10][CH2:9][NH:8][CH3:1]

参加物

4

反応物 1

HCID 665868063-(benzyl(methyl)amino)-N-(2-methoxyethyl)propanamide

生成物 1

HCID 43827811N-(2-methoxyethyl)-3-(methylamino)propanamide収率 28.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of 3-(benzyl(methyl)amino)-N-(2-methoxyethyl)propanamide (1.1 g, 4.39 mmol, 1.00 equiv) in methanol (50 mL) was added 5% palladium-on-carbon (50 mg) and the suspension stirred under a hydrogen atmosphere for 2 h. The solids were filtered out and the mixture was concentrated under vacuum to afford 200 mg (28%) of the product as a white solid.

後処理

  1. filtrationThe solids were filtered out
  2. concentrationthe mixture was concentrated under vacuum

出典と根拠

ORDレコード
ord-c0bc024276584e508e5968bdece29247
出典データセット
uspto-grants-2016_04
特許番号
US09301951B2

反応ノート

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