Potassium Carbonate → Nonanoic acid, 9-hydroxy-, methyl ester
反応式
[CH3:1][O:2][C:3](=[O:14])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11](O)=[O:12].B.CSC.C([O-])([O-])=O.[K+].[K+]>C1COCC1>[CH3:1][O:2][C:3](=[O:14])[CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][OH:12]参加物
5
実験手順
To a solution of nonanedioic acid monomethyl ester (4.80 g, 20 mmol) in THF (20 mL) at −20° C. was added a solution of borane-dimethylsulfide in THF (2.0 M, 10 mL) over 10 min. The resulting mixture was stirred for an additional 10 min, and then allowed to stir at room temperature overnight. Aqueous K2CO3 solution was added, and the product was extracted with ethyl ether (3×). The crude product was purified by flash column chromatography (hexane/EtOAc:2/1) to yield 9-hydroxy-nonanoic acid methyl ester 4-B (2.0 g, 55%).
後処理
- stirringto stir at room temperature overnight
- extractionthe product was extracted with ethyl ether (3×)
- customThe crude product was purified by flash column chromatography (hexane/EtOAc:2/1)
出典と根拠
- ORDレコード
- ord-4ec8fd7e5739410b8e0301f960ca1723
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09308272B2
反応ノート
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