Hydroxyamine hydrochloride → HCID 86674675、化合物
反応式
[CH2:1]([CH:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([O:18][CH3:19])[CH:16]=2)[CH2:11][CH2:10][C:9]1=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:22][OH:23]>C(O)C>[CH2:1]([CH:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([O:18][CH3:19])[CH:16]=2)[CH2:11][CH2:10][C:9]1=[N:22][OH:23])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
反応条件
- 温度
- 65 °C
実験手順
To a solution of 4.47 mmol of 1-benzyl-7-methoxy-3,4-dihydronaphthalen-2(1H)-one in 15 ml ethanol were added 5.59 mmol hydroxylamine hydrochloride (dissolved in 3 ml water). The solution was stirred at 65° C. for 1.5 h. The mixture was cooled to RT and concentrated. The residue was dissolved in methyl tert-butylether and washed with water (2×), dried over MgSO4 and filtered. Evaporation of the solvent gave 1.29 g of 1-benzyl-7-methoxy-3,4-dihydronaphthalen-2(1H)-one oxime (mixture of E- and Z-isomer, 100%).