Methyl chloroformate → HCID 14651533、化合物
反応式
[CH3:1][O:2][C:3](=[O:11])[CH2:4][C@H:5]([CH3:10])[CH2:6][C:7]([OH:9])=[O:8].Cl[C:13]([O:15][CH3:16])=[O:14]>>[CH3:1][O:2][C:3](=[O:11])[CH:4]([C:13]([O:15][CH3:16])=[O:14])[C@H:5]([CH3:10])[CH2:6][C:7]([OH:9])=[O:8]参加物
3
実験手順
Scheme 1 illustrates an exemplary method for making a compound of the formula 1.3. Starting from (R)-5-methoxy-3-methyl-5-oxopentanoic acid, reaction with methyl chloroformate gives (R)-5-methoxy-4-(methoxycarbonyl)-3-methyl-5-oxopentanoic acid, which can be esterified with, for example, trimethylsilyl chloride and methanol to give compound 1.3, (R)-trimethyl 2-methylpropane-1,1,3-tricarboxylate.
出典と根拠
- ORDレコード
- ord-58fb4dbe6f734f54bf72d38c347f879f
- 出典データセット
- uspto-grants-2016_04
- 特許番号
- US09309204B2
反応ノート
読み込み中…